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Five years after the events of 'Sharknado 3', it seems humanity is safe from further shark tornadoes. Aston Reynolds and his company Astro-X are working on a new energy system to stabilize the atmosphere, which is meant to prevent future sharknados. However, an experiment goes wrong and the sharks suddenly appear in places no one would ever expect; in the gambling capital of the world: Las Vegas. Fin, his wife April, April's father Wilford, and Fin's father Gil have to take up their weapons once again to save humanity...